(1R,2S,5S)-methyl 6,6-dimethyl-3-aza-bicyclo[3.1.{10}}]hexane-2-carboxylate Hydrochloride CAS 565456-77-1

Product Description:

(1R,2S,5S)-methyl6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylate hydrochloride CAS 565456-77-1

 

Synonyms:

Boceprevir InterMediates;

Methyl (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate;

 

Chemical & Physical Properties

Cia temp: Inert cua, Chav Kub

Form: khoom

Xim: daj daj

InChI:InChI=1/C9H15NO2.ClH/c1-9(2)5-4-10-7(6(5)9)8(11)12-3;/h{{13} },10H,4H2,1-3H3;1H/t5-,6-,7-;/s3

InChIKey:FKVUDBWXNAFSPB-AUBOPKACNA-N

SMILES:C([C@H]1NC[C@@H]2C(C)(C)[C@H]12)(=O)OC.Cl |&1:1,4,8, r| ib

 

Cov ntaub ntawv kev nyab xeeb

HS Code: 2933998090

 

Siv:

Qhov nruab nrab ntawm Boprevir, uas yog (1R, 2S, 5S) -6, 6-dimethyl-3-azabicyclic [3.1.0] hexane-2-carboxylic acid methyl ester hydrochloride, yog cov saw ntawm Boprevir. Pramivir yog tus kab mob siab C protease inhibitor tsim los ntawm Schering Plough, uas tuaj yeem siv los ua cov tshuaj tseem ceeb ntawm kev kho mob triple (nrog polyethylene glycol - Kev sib xyaw ntawm interferon thiab ribavirin yog siv los kho CHC gene type I chronic hepatitis. peb cov tshuaj tuaj yeem kho tau ntau dua 60% ntawm cov neeg mob, thiab polyethylene glycol ib leeg yog siv - Tus nqi kho mob ntawm interferon lossis ribavirin yog 2 mus rau 3 npaug siab dua, thiab boprivir tuaj yeem txhim kho tus nqi kho thaum tseem txo lub sijhawm kho.

 

Boceprevir (lub npe lag luam Boceprevir), nrog cov tshuaj npe ntawm (1S, 2S, 5S) - N - (4-amino-1-cyclobutyl-3, 4-dioxobutane{{9 }}yl) {{1{{20}}}} [(2S) -2- (tert butylamino) -3,3-dimethylbutyryl] -6 ,6-dimethyl-3-azabicyclo [3.1.0] hexane-2-formamide, yog ib hom kab mob siab C protease inhibitor tsim los ntawm American Chemicalbook Schering Plough, Nws tuaj yeem siv los ua cov tshuaj tseem ceeb rau kev kho triple (ua ke nrog pegylated interferon thiab ribavirin) rau kev kho mob ntawm CHC gene type I chronic hepatitis. Kev sib xyaw ntawm peb cov tshuaj tuaj yeem kho tau ntau dua 60% ntawm cov neeg mob, thiab polyethylene glycol ib leeg yog siv - Tus nqi kho ntawm interferon lossis ribavirin yog 2 mus rau 3 npaug siab dua, thiab boprivir tuaj yeem txhim kho tus nqi kho thaum tseem txo lub sijhawm kho. Cov tshuaj tau pom zoo rau kev lag luam los ntawm US Food and Drug Administration (FDA) thaum lub Tsib Hlis 13, 2011. 1R, 2S, 5S) -6,6-dimethyl-3-azabicyclic [3.1.0 ] hexane-2-carboxylic acid methyl ester hydrochloride (I) yog qhov tseem ceeb nruab nrab nrog tus nqi siab tshaj plaws hauv cov txheej txheem kev sib txuas ntawm cov kab sib txuas ntawm Boprevir.

 

Cov khoom no yog azabicyclohexane derivative, uas tuaj yeem siv los npaj cov kab mob siab C (HCV) NS3 serine protease inhibitor. Lub hom phiaj: Qhov nruab nrab ntawm Boprevir yog cov organic synthesis nruab nrab thiab cov tshuaj nruab nrab, uas tuaj yeem siv rau hauv kev tshawb fawb thiab kev tsim kho cov txheej txheem thiab cov txheej txheem tshuaj lom neeg, feem ntau yog cov qauv thiab siv cov khoom siv.

 

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

 

Cov khoom raws li patent yog muab rau R & D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm kawg tsuas yog nrog tus neeg yuav khoom.

Cim npe nrov: (1r,2s,5s)-methyl 6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylate hydrochloride cas 565456-77-1, manufacturers , lwm tus neeg, Hoobkas, yuav, hauv Tshuag

• Tug: N-Boc-L-tert-Leucine CAS 62965-35-9
• Tom ntej: 6,6-Dimethyl-3-azabicyclo[3.1.