10-Hydroxycamptothecin CAS 19685-09-7

Khoom Piav Qhia:

Khoom Lub Npe: 10-Hydroxycamptothecin CAS TSIS TAU: 19685-09-7

Lub ntsiab lus:

Camptothecin, hydroxy;

Hydroxycamptothecine;

10-OH-camptothecin;

Tshuaj& Lub Cev Muaj Zog:

Tsos: Daj daj

Kev Ntsuas: ≥99.0%

Ceev: 1.60

Melting Point: 265-270 ℃

Kub Point: 820.7 ± 65.0 ℃ (Kwv yees)

Cia Lub Sijhawm: Khaws hauv qhov chaw tsaus, huab cua tsis huv, Khaws hauv lub tub yees, qis dua -20 ℃

Cov Ntaub Ntawv Kev Nyab Xeeb:

Tus lej HS: 2934999090

Cov Lus Hais Txog Kev Nyab Xeeb: S24/25

Camptothecin derivative; topoisomerase inhibitor rau kev kho mob qog noj ntshav. (S) -10-Hydroxycamptothecin yog tus neeg saib xyuas kev kho mob tiv thaiv kab mob siab. IC50 tus nqi: Lub hom phiaj: Hauv vitro: Hauv vitro, 10-hydroxycamptothecin nanosuspensions tso cov tshuaj kaw nrog ze li xoom-xaj kinetics, thiab cov khoom tso tawm mus txog 90% hauv 72 teev. Hauv vitro cytotoxicity kev tshuaj ntsuam pom tias 10-hydroxycamptothecin nanosuspensions tau ua rau muaj kev txhim kho cytotoxicity tiv thaiv HepG2 cells piv rau kev lag luam muaj 10-hydroxycamptothecin txhaj [1]. Hauv vivo: Kev kawm hauv vivo nrog H22 cov qog nqaij hlav thiab txhaj tshuaj ntawm cov tshuaj pom tias hauv kev sib piv rau 10-hydroxycamptothecin txhaj, 10-hydroxycamptothecin nanosuspensions tau nthuav tawm kev txhim kho biodistribution, tshwj xeeb tshaj yog nyob rau hauv lub ntsws (393.40-quav AUC0-24 h, lub siab (192.35-quav AUC0-24 h, tus po) (141.67-fold AUC0 H24 h thiab mob qog noj ntshav (64.21-fold AUC0–24 h. 10-hydroxycamptothecin nanosuspensions) kuj tseem qhia tau tias txhim kho cov tshuaj tiv thaiv kev ua tau zoo ntawm kev txhaj tshuaj (89.83% vs. 30.56%).

Yog tias koj txaus siab rau peb cov khoom lossis muaj lus nug, thov koj xav tiv tauj peb!

Cov khoom lag luam nyob rau hauv patent tau muab rau R& D lub hom phiaj nkaus xwb. Txawm li cas los xij, lub luag haujlwm zaum kawg tshwj xeeb tshaj yog nrog tus neeg yuav khoom.

Cim npe nrov: 10-hydroxycamptothecin cas 19685-09-7, tuam ntxhab, cov chaw muag khoom, lub Hoobkas, yuav, hauv Tshuag

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